Drug hypersensitivity: questionnaire

Drug hypersensitivity is a common and complicated problem in clinical practice. The clinical picture of drug hypersensitivity is very heterogeneous, encompassing such distinct diseases as morbilliform or bullous exanthema, urticaria, anaphylaxis, blood cell dyscrasia, fever, interstitial lung disease, hepatitis, nephritis, and various forms of autoimmune diseases. Drug hypersensitivity has taken over the role of the great imitator of diseases from lues in former times. It is an interesting thought that a better understanding of the pathomechanism of drug allergy may even shed some light on the pathomechanism of those diseases imitated by drug hypersensitivity. The diagnosis of drug hypersensitivity is difficult, and drug-allergic reactions are surely underdiagnosed. This difficulty is related to the following factors: